Zofia Weigl (née Kulikowska; c. 1885–1940) was a Polish biologist who was a collaborator in research to find a vaccine for typhus.
Zofia Weigl became one of her husband's closest collaborators at the Institute.
During the Nazi occupation of Lwów, she became one of the first Louse-feeder who provided human blood for lice infected with typhus. The insects were then used to identify possible vaccines against the disease so the German Army could be protected. By becoming a louse-feeder, one assumed a significant risk of infection, but the people who chose to do this were given extra food rations, were protected from being shipped to slave labor camps and German concentration camps, and were even permitted to move around the occupied city during World War II.
Zofia and Rudolf Weigl had a son, Wiktor (one of his two daughters is psychologist Krystyna Weigl-Albert). The family lived in the Kulikowski family's tenement house at 4 Wagilewicza Street in Lwów. After Zofia's death in 1940, Rudolf's second wife, Anna Herzig, became his assistant.
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